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The Children’s Hospital of Philadelphia Research Institute is an interdisciplinary institution dedicated to conducting basic, clinical and translational research on conditions and diseases that affect children, and is part of The Children's Hospital of Philadelphia and University of Pennsylvania research community.

A postdoctoral fellow position is available at The Research Institute of The Children's Hospital of Philadelphia, an interdisciplinary institution dedicated to conducting basic, clinical and translational research on conditions and diseases that affect children.

The position is working in the laboratory of Dr. John Wolfe, a Principal Investigator within the Neurology Research Division of the Research Institute.

The Post-doctoral position is to study delivery of a therapeutic enzyme into the brain. The project goals are to evaluate AAV transduction in animal models of human diseases and perform pre-clinical toxicology studies for regulatory approval of clinical gene therapy trials. The experiments focus on AAV vector transduction via the ventricular system to deliver secreted therapeutic proteins via the cerebrospinal fluid (CSF) flow, which extends throughout the brain, for global gene delivery to treat neurogenetic diseases. Experience with laboratory animals, neurobiology, molecular biology analysis, and fluorescent and histochemical image analysis is desirable.

Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

The Postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group.

Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results.

Requirements:
- PhD or equivalent with fewer than two years experience after obtaining degree
CV and letters of reference from 2-3 prior employers who can attest to competency and skills in research will be required.
Neurobiology and/or Stem Cell background a plus
- Lab work includes molecular biology, viral vectors, AAV vector, gene therapy for global brain disease
- Species involved in research include mice, cats, dogs, monkeys

SKILLS AND ABILITIES:
Value for research integrity and collaborative research
Requires a high degree of flexibility of hours
Strong research skills
Excellent communication skills/Strong interpersonal skills
Effective problem solving/critical thinking skills.
Ability to work independently and strong work ethic.
Ability to exercise discretion and judgment
High level of motivation.

MANDATORY REQUIREMENTS:
Child Abuse Clearances
FBI Fingerprint Clearance
Drug Screening
Tobacco Screening

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

The Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at The Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products or nicotine in any form and a negative nicotine screen (the latter occurs after a job offer).

The Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status….