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Applications are invited for a postdoctoral research position to join our team of cell biologists and biophysicists at the EMBL Australia Node in Single Molecule Science.

One of the major unsolved issues in immunology is how an extracellular antigen recognition event is linked to the induction of intracellular signals on which T cell fate decisions are based. The overall goal of the project is to gain a better understanding of the nano-scaled organization of T cell receptor (TCR) signalling by using 2- and 3-dimensional single molecule localization microscopy (PALM, dSTORM) in conjunction with molecular control over ligand presentation (e.g. bilayers with pMHC, nanopatterned surfaces and nanoparticles modified with antibodies/pMHC). Specifically, we want to investigate whether a distinct spatial organisation of the TCRis responsible for signal initiation. Further, we would like to link TCR clustering to activation responses, using primary T cells and single cell assays.

A PhD in cell biology, (bio)physics, (bio)chemistry, or related science is required and experience in receptor signalling, cellular immunology, molecular biology and advanced fluorescence microscopy is highly desirable.

The successful postdoctoral candidate will have an active role in conceiving and implementing experimental approaches, training and supervision of research staff and students and presentation of the results in the form of publications, international conference presentations and potentially grant applications….