捷克马萨里克大学招聘脑部疾病和干细胞方向博士后

We are looking for motivated and enthusiastic graduate students and post-doctoral fellows interested in iPSC-based brain disease modelling and stem cell biology. Our laboratory is interested in deciphering the molecular mechanisms underlying schizophrenia using iPSC-based schizophrenic modelling. Experiences with cell culture techniques, stem cell research, microscopy, biochemistry, electrophysiological or molecular biology, iPSC generation techniques are advantageous. Department of Biology, Faculty of Medicine, Masaryk University Brno Research Group: Brain disease modelling and stem cell biology Research Group Leader: Yuh-Man Wadeley, Ph.D.
 

Description

Project information: Substantial progress has been made in the pharmacological treatment of schizophrenia. However, modern antipsychotic medication is still a ssociated with side effects, poor compliance, drug discontinuation, and low efficacy on negative and cognitive symptoms. This field mainly lacks a sensitive means to assess the effects of drugs on the brain cells, which control our thinking and behaviour. The advent of induced pluripotent stem cell (iPSC) technology renders a breakthrough to convert skin cells, or other cell types, into brain cells (e.g., neurons, astrocytes, and oligodentrocyts), whereby patient-specific brain cells can be expanded and examined in a petri dish. This project is to employ iPSC technology to establish a therapeutic platform for individual patients, which conjoins in-vivo and in-vitro approaches to test the effects of antipsychotic drugs. The outcome of drug assessments will be used to recommend a patient’s future drug therapy. Employment Conditions: We offer a competitive salary that will be based on the candidate`s qualifications and experience. Please send CV, short statement of research background/ interests and the contact information of at least three references by email to: wadeley@med.muni.cz Electronic applications deadline is April 30, 2015.