美国芝加哥大学癌症研究博士后职位

POSTDOCTORAL RESEARCH POSITION at the University of Chicago, Chicago (U of C). One NIH-funded position is available for a highly motivated Ph.D. or M.D. interested in translational cancer research. The overall goal of the laboratory is to enhance our understanding human fallopian tube and ovarian cancer biology. The intended project will focus on the role of fibronectin in ovarian carcinogenesis and metastasis. Specifically, we use biochemical analysis to identify and characterize the predominant forms of fibronectin present in high-grade serous ovarian cancer. In addition, we continue to develop new treatments founded on blocking the interaction of stromal and cancer cells with fibronectin (see Journal of Clinical Investigation 2008 118(4):1367-79, 2014 124(10):4614-28, Nature Communications 2015 Feb 5;6:6220, Nature Medicine, 2011 Oct 30; 17(11):1498-503).

The approaches we take encompass primary cell and organ culture, mammalian cell culture, molecular biology, structural biochemistry, biochemistry, genomics, and transgenic mouse models. As a translational research laboratory, we have access to primary human tissue, including tissue microarrays for ovarian cancer. We collaborate with the pharmaceutical industry to test new compounds for ovarian cancer treatment in vitro and in vivo, and are part of phase I and phase II clinical studies examining new treatments for gynecologic cancers. The laboratory (http://obgyn.bsd.uchicago.edu/FacultyResearch/lengyellab.html) currently employs 8 postdoctoral scientists and five research support assistants, and is situated in the Gordon Center for Integrative Science at the University of Chicago. The Center provides laboratory space for approximately 40 different research groups and encourages an integrative approach to science by bringing a Howard Hughes Medical Institute, biochemists, structural biologists, chemists, and cancer biologists together under one roof.

We offer comprehensive training in translational research with access to all aspects of basic and clinical cancer treatment. A strong background in molecular and cellular biology is essential and expertise in protein biochemistry and/or transgenic mouse models preferential. We are seeking candidates who are self-motivated and career-oriented and who want to take full advantage of the opportunities given. Our approach to science is highly collaborative.