| Employer: |
Washington University School of Medicine |
| Job Number: |
4015752 |
| Date Posted: |
03/08/2015 |
| Application Deadline: |
Open Until Filled |
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Job Description
Descriptions:
An opportunity is immediately available for a Postdoctoral Research Associate at the Washington University Renal Division. Endoplasmic reticulum (ER) dysfunction and protein misfolding diseases caused by gene mutations is an emerging field. As a physician-scientist, a main focus of my lab is to understand the molecular mechanisms of glomerular disease and proteinuria caused by podocyte gene mutations. Currently we are investigating the role of podocyte ER stress in the pathogenesis of nephrotic syndrome, seeking biomarkers of podocyte ER stress, and exploring novel treatments (J Am Soc Nephrol. 22: 849-858 2011; J Am Soc Nephrol. 24: 1223-1233 2013; a provisional US patent related to the discovery of a novel ER stress marker in kidney diseases). The second focus in the laboratory is to study the crosstalk between podocytes and glomerular endothelial cells (GECs) / peritubular capillary ECs in a variety of kidney diseases including nephrotic syndrome and renal fibrosis. We are using cutting-edge research approaches including mammalian cell culture, molecular and cell biology, biochemistry, inducible transgenic and conditional knock-out animal models, genomic methods, and state-of-the-art in vitro & in vivo imaging techniques. We also have access to two major nephrotic syndrome patient cohorts to acquire human patient data bases including DNA sequence, gene expression and histology from kidney biopsies, and urine samples. The PI’s research is currently funded by NIH, the Children’s Discovery Institute, American Society of Nephrology, and industry.
Required Qualifications:
A PhD or MD/PhD degree in biochemistry, molecular biology, cell biology or other related fields is required. Previous experience with mouse genetic models of human diseases or kidney-related research or strong background and skills in molecular biology or biochemistry is highly desired, but not required. If you are a US permanent resident, you may be eligible for an NIH T32 Postdoc training grant.
Department Summary:
The Washington University Renal Division (http://renal.dom.wustl.edu/) has been ranked as top ten by US News & World Report every year since ratings began. The research environment is outstanding.
Salary Range:
Commensurate with experience. Provide excellent fringe benefits.
Applicant Special Instructions:
All the important tools including mouse genetic models have been set up in the lab for multiple projects. If you are a career-oriented and highly-motivated researcher who intends to be productive in the Postdoc period, please email a CV, a cover letter and the names of three references to:
Y. Maggie Chen, MD, PhD
Assistant Professor of Medicine
Renal Division
Washington University School of Medicine
Box 8126
660 S. Euclid Avenue
St. Louis, MO 63110
Email: ychen@dom.wustl.edu |
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