PostDoc Lead Discovery : Berlin, Germany

YOUR TASKS AND RESPONSIBILITIES
• Responsible for the investigation of small molecule-drug target interactions focusing on the driving forces of binding affinity and binding kinetics
• Drive project progression by determining Structure-Activity and Structure-Kinetic Relationships (SAR and SKR) of a selected set of target proteins and small molecules
• Application of a wide variety of technologies, including Surface Plasmon Resonance and
cell-based assays as well as X-ray structure analysis to describe molecular aspects of binding kinetics in vitro
• Close collaboration and exchange within cross-disciplinary teams as well as within an academic and industrial research consortium (IMI Kinetics for Drug Discovery)
• Highly encouraged to publish recent results in peer-reviewed journals and to present findings at international conferences

WHO YOU ARE
• PhD in biochemistry, biophysics, pharmacy or related disciplines
• In-depth knowledge of biophysical or enzymological methods to study reaction and binding kinetics
• Considerable experience in protein biochemistry, characterization of protein-ligand complexes as well as protein structure determination by X-ray crystallography
• Sound understanding of the principles of pharmacokinetics and pharmacodynamics is beneficial
• Experience with cell-based assays is a plus
• Demonstrated ability to contribute to scientific projects in a highly creative and independent manner
• Passion to undertake challenging scientific tasks along with an outstanding problem solving ability
• Ability to effectively work in multidisciplinary teams
• Excellent written and verbal communication skills

YOUR APPLICATION
This is a fixed-term contract for two years.
We offer a competitive salary and benefits package and support both individual and professional development. Applications for this position should be made online at www.career.bayer.de, submitting a cover letter, your CV and references as well as your salary expectation