当前位置:首页>>博士后之家>>国外博士后招聘>>正文内容

美国梅奥诊所基因转录异常研究博士后职位

2014年10月23日
来源:知识人网整理
摘要:
Abnormal gene transcription often leads to human diseases such as cancer. The research program in Professor Haojie Huang’s laboratory at Mayo Clinic primarily focuses on regulation and function of biologically significant factors that control gene transcription, such as transcription factors (androgen receptor (AR), FOXO1 and ERG), ubiquitin E3 ligase mutated in cancer such as SPOP, histone/chromatin modifiers (methyltransferase EZH2 and histone demethylase LSD1). Using the state-of-the-art approaches including mouse genetics, biochemistry, molecular and cell biology, high throughput sequencing (RNA-seq, ChIP-seq and RIP-seq) and bioinformatics, Dr. Huang’s laboratory aims to elucidate the role of deregulated PTEN/FOXO1 pathway in prostate cancer survival, glucose and lipid metabolism