挪威奥斯陆大学免疫生物学、分子生物学博士后职位

Two 2-year postdoctoral research fellowship positions are available at the Research Council of Norway project “The intracellular pathway for MHC Class II antigen presentation”. One of the positions will work in the group of prof. Oddmund Bakke at the Department of Biosciences and the second in the group of Dr. Preben Morth at the Centre for Molecular Medicine, University of Oslo. A one-year prolongation is possible.

Job Description

The project focuses primarily on unraveling the function of the endocytic pathway toward antigen loading using biophysical techniques, molecular biological techniques, protein crystallography, biochemistry, imaging (e.g. live imaging) and molecular/imaging/biochemical screens in cell culture systems and cells from knock out/knock in mice. The project will focus on unraveling the pathway towards MHC II antigen loading, in particular for the molecules that associate with the transport to and from this compartment in immune cells (See e.g. Neefjes et al., 2011, Nature immunology). We also work, together with a clinical group, on testing vaccines for immunotherapy by improving loading of the MHC molecules. The Morth Group is a part of the Centre for Molecular Medicine Norway. The Bakke group is a member of a CoE, Centre for Immune Regulation and prof. Oddmund Bakke is also the head of the National imaging platform NorMIC Oslo, with a wide range of imaging equipment. For more information regarding the Bakke group, see their web page.

The work will include collaboration with national and international groups in particular prof. Jacques Neefjes at the Dutch Cancer Centre, NKI in Amsterdam.

We are seeking highly motivated and skilled researchers with broad and extensive experience within one or more of the following areas: advanced imaging, molecular biology, cellular immunology, cell biology, biochemistry, and protein chemistry. Prior experience with intracellular membrane/protein traffic and library screening will be considered a strong advantage. One of the positions will preferentially have experience with protein crystallography and/or biophysical methods.

Qualifications

The Faculty of Mathematics and Natural Sciences has a strategic ambition of being a leading research faculty. Candidates for these fellowships will be selected in accordance with this, and expected to be in the upper segment of their class with respect to academic credentials.

The candidates must have a PhD or other corresponding education equivalent to a Norwegian doctoral degree in molecular biology, cell biology, biophysics or biochemistry or structural biology….