Research Fellow : Ann Arbor, MI, United States

Multiple postdoctoral positions available studying the systems biology of bacterial regulatory networks

We are seeking highly motivated postdocs to join a team applying interdisciplinary methods to map and quantitatively model bacterial regulatory networks. We use a combination of experiments in microbial physiology, systems-level measurements of biomolecular interactions, and physics-based multiscale modeling to develop a quantitative, predictive understanding of the logic of bacterial regulatory networks, the evolutionary history encoded in them, and the ways in which they shape the responses of bacterial cells to new stress conditions. The development of accurate, predictive models of bacterial gene regulation will be of enormous benefit for basic research, antibiotic development, and synthetic biology applications. Positions are available for candidates with interest and/or expertise in any of the following four areas:

1. Microbial physiology – projects available focused on characterizing bacterial growth in response to different combinations of stress conditions, and identifying the biological basis for cross-protection and cross-sensitization of these stressors
2. Systems-level measurements of biomolecular interactions – projects available focused on applying methods such as ChIP-seq and HT-SELEX to identify the complete molecular basis for bacterial behavior under changing conditions
3. Molecular modeling – projects available focused on large-scale modeling of protein-DNA and protein-protein interactions, and the development and parameterization of coarse-grained models of gene regulation parameterized by high throughput experiments
4. Bioinformatics – projects available focused on analyzing high throughput measurements of gene expression and biomolecular interactions to infer regulatory network structure and the identity and function of unknown regulators

As we aim to establish a cohesive and interdisciplinary team, preference will be shown for candidates with research interests in more than one of the above areas. Considerable flexibility is available on the exact research path to be taken, as long as projects fall within the broad interests and capabilities of the lab. Positions are available starting January 1, 2015. For more information on the laboratory, seehttp://www.biochem.med.umich.edu/?q=freddolino

To apply, upload a CV, cover letter, and list of three references to http://umjobs.org/job_detail/apply/97786. Your cover letter should outline your recent research accomplishments, the reason for your interest in our work, the pertinent skill sets that you already possess, and the new research proficiencies you hope to build during your postdoctoral work….