美国约翰霍普金斯大学人类环境表现基因组实验室招聘博士后

The laboratory of Human Environmental Epigenomes of Dr. Zhibin Wang at Johns Hopkins University is looking for one or two postdoctoral fellow(s) to join a hot field of human epigenomes. The Wang laboratory has been pioneering with their developed ChIP-seq method and other deep sequencing methods (for example, RNA-seq and BS-seq) to answer how epigenetic codes are involved in the pathogenesis of human diseases. Current research efforts are centered on: 1) How DNA methylation patterns control genomic imprinting, gene transcription, and genome stability. We have developed novel approaches to identify 17 unknown imprinted loci with roles in many common diseases, and we are characterizing the crosstalk of DNA methylation and histone methylation in establishing chromatin structure. Ongoing projects include: (1) Distinct roles of DNMT1-dependent and –independent patterns in the genome of mouse ES cells (under review); (2) High throughput characterization of differentially-methylated-regions and their control of bivalency composition in the mouse genome. 2) How histone modifying complexes modulate three layers of chromatin (histone acetylation/methylation, nucleosome positioning, and exchange of histone variant H2A.Z/H3.3). We are looking for young scientists who are highly motivated and can critically think their research projects. Publications to demonstrate the training in molecular biology/biochemistry are required. Background in genomic imprinting, gene transcription, chromatin remodeling, and stem cell biology is preferred. Experience of computational programs and/or bioinformatic analyses is a plus.

Johns Hopkins is a premier university in the world. Schools of Public Health/Nurse/Medicine and Hospital of JHU are the best in US year in and year out, according to US News and World Reports. Hopkins’ prominence is also evidenced by the fact of leading U.S. academic institution in total research and development spending for the 33rd year in a row, according to National Science Foundation ranking. Baltimore/DC area is nice to live with diverse communities and has lots museums that are free to visit.